zanubrutinib in relapsed/refractory mantle cell lymphoma: long-term efficacy and safety results from a phase 2 study
Answers
The phase 2 study evaluated the long-term efficacy and safety of zanubrutinib in relapsed/refractory mantle cell lymphoma. Zanubrutinib is a targeted therapy that works by inhibiting a specific protein called Bruton's tyrosine kinase (BTK), which is involved in the growth and survival of lymphoma cells.
The study aimed to assess the effectiveness of zanubrutinib in treating patients with mantle cell lymphoma that had either relapsed (returned after initial treatment) or was refractory (did not respond to initial treatment).
The long-term efficacy results showed promising outcomes. The overall response rate (ORR) was found to be high, with a significant proportion of patients experiencing partial or complete responses to zanubrutinib treatment. This indicates that zanubrutinib has the potential to effectively control the progression of mantle cell lymphoma in these patients.
In terms of safety, the study reported a manageable and tolerable safety profile for zanubrutinib. Adverse events were observed, but most were mild to moderate in severity. Common side effects included diarrhea, fatigue, and nausea.
Overall, the phase 2 study suggests that zanubrutinib is a promising treatment option for patients with relapsed/refractory mantle cell lymphoma. Its long-term efficacy results and manageable safety profile make it an attractive therapeutic option for these patients.
Further studies and clinical trials are needed to validate these findings and assess the long-term benefits and potential side effects of zanubrutinib in a larger patient population.
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Related Questions
Where do plants get the nitrogen they need to create amino acids and DNA?
A. Plants get their nitrogen from nitrogen gas (N2), which moves into leaves through holes called stomata.
B. Plants take up nitrates (NO3-) from the soil and convert them into ammonia (NH3).
C. Nitrogen-fixing bacteria convert nitrogen gas (N2) into ammonia (NH3), and plants take up some of the ammonia (NH3) through their roots.
D. Both B and C are correct.
E. A, B, and C are all correct.
Answers
Answer: It is D because they get it from soil and the gas
Plants get the nitrogen they need to create amino acids and DNA - option D. Option B and option C are correct.
Plants get nitrogen which is essential to form amino acid and nucleic acid that is DNA. Plants can not get the nitrogen gas directly from the air therefore, the process called nitrogen fixation takes place.
In nitrogen fixation, atmospheric nitrogen is converted to nitrates and ammonia with the help of nitrogen-fixing bacteria.Lightning and rainstorm also assist in the fixation process.plants take up nitrate from the soil and convert them into ammoniaNitrogen gas is converted into ammonia (NH3) by bacteria, and plants take up some of the ammonia (NH3) through their roots to the shoot via the xylem.Thus, the correct answer is - option D. both B and C are correct.
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The nervous system and the muscle system respond to stimuli to produce motion. The movements of
muscles are mostly voluntary. Involuntary movements occur in these muscles when the nerve impulse passes from a sensory neuron to a motor neuron via an interneuron in the
.
Answers
The nervous system and the muscle system respond to stimuli to produce motion. The skeletal movements of muscles are mostly voluntary.
Involuntary movements occur in these muscles when the nerve impulse passes from a sensory neuron to a motor neuron via an interneuron in the spinal cord.
What are Skeletal muscles?Skeletal muscles may be defined as the muscles that fasten to your bones and authorize you to achieve a broad range of activities and operations.
Skeletal muscles control the direct movement of a person's will and are hence referred to as voluntary movement.
While the spinal cord is associated with both movements directly or indirectly. It is a prolonged, delicate tubelike network liable for holding incoming and outgoing messages through the brain to the rest body.
Therefore, it is well described above.
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State three adaptations of acquatic plants to photosynthesis
Answers
Answer:
Aquatic plants have evolved aerenchyma tissue to transport oxygen from the surface to the roots, recycle carbon dioxide from cellular respiration to do photosynthesis, and keep the plant buoyant in water.
Aquatic plants also use bicarbonate, which is more plentiful under water, as a carbon source.
Explanation:
Ribosomes are the site where
protiens
are produced.
Amino acids are coded for by triplet bases in RNA called
condon
.
Answers
Answer:
That's true
Explanation:
But remember. What is produced actually is not a protein. It is a petide chain which is the first structure of protein.
When the peptide chain reaches its fourth structure ،it csn have its function in body.
Thats a complete protein.
Hope it helps.
atoms are not created or destroyed during a chemical reaction scientists know hat there must be the same number of atoms on each side of the equation to balance the chemical equation you must add coefficient in front of the chemical formulas in the equation you cannot _____or ______subscripts
fill in the blank
Answers
You cannot change or alter subscripts in a chemical equation.
Which law states atomic indivisibility?The law that states atomic indivisibility is known as the Law of Conservation of Mass. This law, also known as Lavoisier's Law, was proposed by French chemist Antoine Lavoisier in the late 18th century. It states that in any chemical reaction, the total mass of the reactants must equal the total mass of the products.
This law implies that atoms are indivisible and cannot be created or destroyed in a chemical reaction. While this law has been modified with the discovery of subatomic particles and nuclear reactions, the concept of atomic indivisibility remains an important foundational principle in modern physics and chemistry.
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unicellular organisms that lack a nucleus are called
Answers
Unicellular organisms that lack a nucleus are called prokaryotes.
Organisms are said to be prokaryotes if their cells do not include a nucleus or any other organelles. Bacteria and archaea are the two separate groups that make up prokaryotes and scientists believe that both of these groupings have their own independent evolutionary lineages. The majority of prokaryotes are single-celled, tiny organisms that have a structure that is quite straightforward.
The nucleus of prokaryotic cells does not contain a nuclear membrane since these organisms are unicellular and primitive. They do not have any organelles that are bound to the cell membrane.
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why i choose biotechnology essay
Answers
Biotechnology is a rapidly growing field that offers numerous opportunities for innovation and discovery. There are many reasons why someone might choose to study biotechnology.
Why biotechnology?Advancements in biotechnology have the potential to improve human health and well-being by creating new treatments for diseases, enhancing the effectiveness of existing therapies, and even developing cures for previously incurable conditions.
Biotechnology is a rapidly growing field with a wide range of applications, from agriculture and food science to environmental sustainability and renewable energy. This makes it a dynamic and exciting area of study that offers a wealth of career opportunities.
The development of new biotechnologies is often interdisciplinary, requiring knowledge from multiple fields such as biology, chemistry, engineering, and computer science. This interdisciplinary approach can be appealing to individuals who enjoy working at the intersection of different fields.
Biotechnology offers the opportunity to work on important global issues, such as food security, energy production, and the environment. This can be incredibly rewarding, as individuals in the field have the ability to make a significant impact on the world.
Biotechnology is constantly evolving, so individuals in the field have the opportunity to work on cutting-edge research and be at the forefront of technological advancements.
Overall, biotechnology is a fascinating and challenging field that offers numerous opportunities for innovation, discovery, and making a positive impact on the world.
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Which of the following best describes how species are defined under the General Lineage Concept?
A. An interbreeding population that is reproductively isolated from other populations
B. Groups of organisms that look the same, but live in different ranges
C. Independently evolving lineages
D. The product of genetic drift
Answers
The best description of how species are defined under the General Lineage Concept is that they are independently evolving lineages. This concept focuses on the evolutionary history of organisms and recognizes that species can evolve and diverge even if they do not interbreed.
The General Lineage Concept is a way of defining species based on independently evolving lineages. According to this concept, species are groups of organisms that have a common ancestor and share a lineage that has been evolving separately from other lineages.
Option C, "Independently evolving lineages," best describes how species are defined under the General Lineage Concept. This means that a species is a distinct evolutionary lineage that has its own unique characteristics and traits.
Unlike option A, which mentions interbreeding populations, the General Lineage Concept focuses on the evolutionary history of organisms rather than their ability to reproduce with each other. It recognizes that species can evolve and diverge even if they do not interbreed.
Option B, which mentions groups of organisms that look the same but live in different ranges, is not accurate according to the General Lineage Concept. Species can look different from each other and still belong to the same lineage, or they can look similar but belong to different lineages.
Option D, which mentions genetic drift, is not specific to the General Lineage Concept. Genetic drift is a random process that can affect the genetic makeup of populations, but it is not the sole factor in defining species under this concept.
In summary, the best description of how species are defined under the General Lineage Concept is that they are independently evolving lineages. This concept focuses on the evolutionary history of organisms and recognizes that species can evolve and diverge even if they do not interbreed.
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what is the importance of oxygen
Answers
Hello True Beauty fan!
Most living things need oxygen to survive. Oxygen helps organisms grow, reproduce, and turn food into energy. . Oxygen gives our cells the ability to break down food in order to get the energy we need to survive.
Oxygen is essential to have efficient cellular respiration; most organisms need oxygen for a single purpose: to release energy from food for use by cells.
Cross two pink snapdragons. What is the genotypic and phenotypic probability of such a cross?
Answers
Answer:
Genotypic probability = 1RR: 2Rr: 1rr
Phenotypic probability = 1Red: 2Pink: 1white
Explanation:
This question involves a single gene coding for skin color in snapdragon plants. The alleles are incompletely dominant over one another and hence, produce an intermediate pink phenotype.
According to this question, two pink/heterozygous snapdragons were crossed i.e. Rr × Rr. Each parent will have gametes R and r. Using these gametes in a punnet square (see attached image), the following proportion of offsprings will be produced:
Genotypic probability = 1RR: 2Rr: 1rr
Phenotypic probability = 1Red: 2Pink: 1white
А (blank)
is a chemical substance that organisms require to live.
Answers
Answer:
Nutrient
Explanation:
Nutrients are compounds in foods which are essential to life and health of living organisms, providing them with energy. They are the building blocks for repair and growth and substances necessary to regulate chemical processes. There are six major nutrients:
Carbohydrates,Lipids (fats),Proteins,Vitamins,Minerals,Water.(PLEASE HELP I AM TIMED) Read the sentences from the section "How to Teach Students Vaping Is Dangerous?" and the section "Parents Need to Set the Tone at Home."
"I would rather convince a kid to not start, than to ever have to convince them to stop," Principal Gregg Wieczorek said.
Parents are key allies and must set the tone at home that there is a zero-tolerance policy for drugs, school officials say.
Which option BEST describes the relationship between the two sentences?
(A) The first explains an effect and the second sentence explains the cause of that effect.
(B) The first states an idea and the second provides an example of that idea.
(C) The first highlights a problem while the second gives a solution to that problem.
(D) The first shows an action taken by someone and the second shows the reaction to it.
Answers
Answer:
B
Explanation:
A scientist investigated the radiation sensitivity of different mammals to x-rays to determine the LD50 within 30 days. Results from the study are included below. Based on the LD50 data in the table, which of the following equations should be used to calculate how many times greater the resistance of a rabbit to x-rays is than that of a dog?
A 800 - 325
B 800 + 325
C 800 * 325
D 800/325
Answers
That the resistance of a rabbit to x-rays is 2.46 times greater than that of a dog. In other words, a rabbit can tolerate almost 2.5 times more radiation than a dog before succumbing to the effects.
The LD50 values represent the dose of x-rays required to cause death in 50% of the animals within 30 days. The higher the LD50 value, the more resistant the mammal is to x-rays. To determine how many times greater the resistance of a rabbit is to x-rays compared to a dog, we need to divide the LD50 value for the rabbit by the LD50 value for the dog.
LD50 for rabbit = 800
LD50 for dog = 325
So, the equation that should be used is D) 800/325.
800/325 = 2.46
This means that the resistance of a rabbit to x-rays is 2.46 times greater than that of a dog. In other words, a rabbit can tolerate almost 2.5 times more radiation than a dog before succumbing to the effects.
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(k) During biological N removal, what happens in the anoxic zone? i) NOx generation ii) High in NOx iii) Converting NOx to N2 iv) No additional organic addition (1) Which EPA requirement should be fulfilled to apply biosolids to land without further pathogen regulation? i) Class A requirement ii) Class B requirement iii) 1" biosolids requirement iv) Class 1 requirement (m) Which is more acutely toxic? i) LD50 = 5 mg/kg BW ii) LD50 = 1000 mg/kg BW (n) Under what circumstances can a registered engineer sign and seal plans or documents he/she did not prepare? i) Registered engineers can coordinate ii) Under no circumstances. projects that include segments that they are not competent in if a qualified registered engineer signs and scals plans or documents for those segments of the project iii) If the plans or documents were prepared iv) When practicing in a state different than by someone under the registered engineer's the one in which the engineer is registered. direct supervision and the registered engineer is an expert in the subject matter.
Answers
what is a typical early sign of cancer in the ascending colon?
Answers
A typical early sign of cancer in the ascending colon, which is the first part of the colon, is often a change in bowel habits. This can include persistent constipation or diarrhea, as well as a change in the consistency or size of the stool
A common early sign of cancer in the ascending colon, which is located at the beginning of the large intestine on the right side of the abdomen, is abdominal discomfort or pain. This can be accompanied by bloating, cramping, or a feeling of fullness even after a bowel movement. Other early symptoms may include changes in bowel habits, such as diarrhea or constipation, blood in the stool, or unexplained weight loss.
However, it is important to note that these symptoms can also be caused by a variety of other conditions and do not necessarily indicate cancer. Regular screening for colon cancer is recommended for individuals over the age of 50, or earlier if there is a family history of the disease. If you are experiencing any persistent symptoms or have concerns about your risk for colon cancer, it is important to consult with your healthcare provider.
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Is this statement true or false?
There is nothing we can do to help prevent soil erosion. Only scientists and farmers can work on solutions.
Answers
Answer:
FALSE!
Explanation:
The more you anticipate and pre meditate ways to help this field of economical science, there is at least 1 or more ways to help this situation. We could help by doing research and doing community service dealign with this specific issue and help fix the problem community by community! hope this helps!
An astronaut is planning a trip to a newly-discovered planet according to the law of universal gravitation, the astronaut weight in the new planet will be greater than his weight on earth if:
Answers
The new planet has more mass than Earth but the same radius. The mass of the astronaut will be calculated by the use of Newton's gravitational equation. The weight of the astronaut depends completely on its mass and the gravitational acceleration of the planet.
Gravitational acceleration is directly proportional to the mass of the planet and indirectly proportional to the radius of the planet. Hence, when the gravitational acceleration increases the planet's mass will increase therefore the radius will decrease. The astronaut's mass will depend on these factors.
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Which of the following are branches of the autonomic nervous system and innervate the gastrointestinal tract
Answers
Both the sympathetic and parasympathetic branches of the autonomic nervous system provide innervation to the gastrointestinal tract, but they exert opposing effects on its function. The balance between these two branches helps regulate and maintain the optimal functioning of the digestive system.
The branches of the autonomic nervous system that innervate the gastrointestinal tract are: Sympathetic Nervous System: The sympathetic division of the autonomic nervous system typically inhibits gastrointestinal activity. It is responsible for the "fight or flight" response and prepares the body for physical exertion or stressful situations. Sympathetic fibers innervate the gastrointestinal tract and can decrease digestive functions such as peristalsis and secretion. Parasympathetic Nervous System: The parasympathetic division of the autonomic nervous system promotes gastrointestinal activity. It is responsible for the "rest and digest" response, conserving energy and promoting digestion. Parasympathetic fibers innervate the gastrointestinal tract and can stimulate digestive functions such as peristalsis, secretion, and vasodilation. Both the sympathetic and parasympathetic branches of the autonomic nervous system provide innervation to the gastrointestinal tract, but they exert opposing effects on its function. The balance between these two branches helps regulate and maintain the optimal functioning of the digestive system.
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Genes are used to make RNA and some RNA is used to make proteins. Not all RNAs in the cell are destined to be translated. What RNAs will be translated?
Multiple Choice:
tRNAs
mRNAs
tRNAs and mRNAs
rRNAs and mRNAs
tRNAs, mRNAs and rRNAs
Answers
Out of the given multiple-choice options, the correct answer is:
mRNAs
In the process of translation, only
messenger RNAs
(mRNAs) are used to
synthesize proteins
. Transfer RNAs (tRNAs) and ribosomal RNAs (rRNAs) play important roles in translation, but they are not directly translated themselves.
What is
translation?
The process of polymerization of amino acid to form a polypeptide is called translation. Thus, the biological process through which protein is synthesized is called translation.
Steps of translation are described below:
1)The ribosomal RNA binds to the messenger RNA at a specific area
2) The tRNA starts matching its anticodon to the codon of mRNA
3) The tRNA carries an amino acid on other side and the amino acid forms a peptide bond with the previous amino acid.
4) This process carries on until a stop codon is encountered. Then messenger RNA is released.
5) The protein thus released forms into its native structure and acts as a functional protein.
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What causes cirrhosis of the liver other than alcohol?.
Answers
Answer:
Chronic hepatitis B and hepatitis D
Post-Lab Analysis:
Research the pathway of how oxygen is taken from the atmosphere to how it is used by our muscle tissue.
Double click on the text box below. Correctly arrange the steps of the pathway by arranging the boxes from top to button.
Red blood cells carry oxygen to the muscle tissues of the body (cells)
Oxygen in the circulatory system (blood) attaches to the hemoglobin molecule on red blood-cells
The muscle tissues use the ATP molecule to function properly
Oxygen diffuses across the cell membrane of the cell
Inhaled oxygen travels through the respiratory system to the lungs
The oxygen in the lungs diffuses to the circulatory system (blood)
Oxygen in the air is inhaled by the respiratory system (nose and mouth)
Oxygen inside the muscle cell is used by the mitochondria to produce the energy molecule adenosine triphosphate (ATP).
Answers
Answer:
Oxygen in the air is inhaled by the respiratory system (nose and mouth)Inhaled oxygen travels through the respiratory system to the lungsThe oxygen in the lungs diffuses to the circulatory system (blood)Oxygen in the circulatory system (blood) attaches to the hemoglobin molecule on red blood-cellsRed blood cells carry oxygen to the muscle tissues of the body (cells)Oxygen diffuses across the cell membrane of the cellOxygen inside the muscle cell is used by the mitochondria to produce the energy molecule adenosine triphosphate (ATP).The muscle tissues use the ATP molecule to function properlywhats the process of (kepler-186f) fusion between these atoms that occurs in all-stars
Answers
Answer: the main element
Explanation: vamp
summary of the electron transport chain
Answers
The electron transport chain is a process that moves hydrogen ions across a membrane to produce large amounts of ATP.
The final step in transferring the energy of sunlight and glucose to the usable energy of ATP takes place during the electron transport chain. This step is a complex process, but in the end, the amount of ATP produced allows complex life to flourish on earth.
The last stage of cellular respiration is the electron transport chain.
The last phase of cellular respiration is the electron transport chain . The electron transport chain cranks out large amounts of ATP—in fact, it produces most of the ATP that a cell needs to drive all of its processes. In this stage, the electron carriers NADH and FADH2 that were produced in the Krebs cycle are ready to donate their energy to produce ATP.
As with glycolysis and the Krebs cycle, you don't need to memorize every detail of the electron transport chain. Rather, it is important that you learn the main components of the process and have a basic understanding of what goes on.
The electron transport chain takes place within the inner membrane of the mitochondria.
Recall that mitochondria have two membranes—an inner membrane and an outer membrane. The folds of the inner membrane, or cristae , create a very large surface area.
The electron transport chain takes place in the cristae. The large surface area of the cristae allows many substances to cross the membrane at one time.
Which statement best describes the movement of carbon dioxide into or out
of a plant during photosynthesis?
A. It is given off into the soil.
B. It is taken in from the soil.
C. It is given off into the air.
D. It is taken in from the air.
Answers
Answer:
D it is taken in from the air
Explanation:
Carbon dioxide is in the air and plants use it to make food.
Answer:
D : It is taken in from the air
Explanation:
Got it correct on a p e x
Hope this helps!
Aerobic Exercise Training-Induced Changes on DNA Methylation in Mild Cognitively Impaired Elderly African Americans: Gene, Exercise, and Memory Study - GEMS-I
Answers
Aerobic Exercise Training-Induced Changes on DNA Methylation in Mild Cognitively Impaired Elderly African Americans: Gene, Exercise, and Memory Study - GEMS-I is a study conducted to analyze the effect of aerobic exercise on DNA methylation and memory in mild cognitively impaired elderly African Americans. This study was conducted by analyzing the samples of 65 adults aged between 55-89 years with mild cognitive impairment.
The main aim of this study was to understand the relationship between aerobic exercise and DNA methylation in mild cognitively impaired elderly African Americans. The study is important as it could help in developing new therapies to treat mild cognitive impairment.The study found that aerobic exercise could lead to an increase in DNA methylation. DNA methylation is a process of adding a methyl group to DNA that changes the gene expression without changing the underlying DNA sequence. This change in gene expression could help in the improvement of cognitive functions.
The study also found that aerobic exercise could lead to an improvement in memory in mild cognitively impaired elderly African Americans. This is important as mild cognitive impairment could progress to Alzheimer's disease.Aerobic exercise is a physical exercise that increases the heart rate and oxygen consumption. This type of exercise has several health benefits and is recommended for people of all ages. The GEMS-I study has shown that aerobic exercise could also have cognitive benefits.
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4. Exercise 3.4. Genetic Testing and Insurance Prices. Suppose the likelihood that a person will get disease X is determined in large part (but not exclusively) by his or her genes. Initially, it Is impossible to determine who carries the gene for the disease, and many people spend $500 on special health insurance to cover the costs of treatment for the disease. Suppose scientists uncover the gene responsible for the disease and develop a simple test for the gene. (Related to Application 3.) a. Suppose the government passes a law that prevents insurance companies from getting the results of a customer's genetic test for X. Will the new price of X insurance be greater that or less than $500 ? b. Suppose insurance companies have access to the results of genetic tests and they require all customers to get the test. How will the insurance company change its price of X insurance?
Answers
The first scenario's price of X insurance will be greater than $500, while the second scenario's price of X insurance depends on the results of the genetic test.
a) If the government passes a law that prevents insurance companies from getting the results of a customer's genetic test for X, the new price of X insurance will be greater than $500.
b) If insurance companies have access to the results of genetic tests and they require all customers to get the test, the insurance company will change its price of X insurance as follows: if the test shows that a customer has the gene, the insurance company will raise the price of insurance to $800 to cover the expected treatment cost of $10,000 (with probability 1). In contrast, if the test shows that a customer does not have the gene, then the insurance company will lower the price of insurance to $100 to cover only administrative costs, assuming there is no risk of developing the disease.
According to these two scenarios, the first scenario's price of X insurance will be greater than $500, while the second scenario's price of X insurance depends on the results of the genetic test.
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The primary function of the muscular system is:
delivering nutrients
O movement
protection
O immune r ponse
Help ASAP
Answers
The primary function of the muscular system is movement.
What is muscles?
The muscular system is a group of organs that includes skeletal, smooth, and cardiac muscle. It allows the body to move, maintains posture, and circulates blood throughout the body. Although some muscles (such as the heart muscle) are entirely autonomous, the nervous system controls the muscular systems in vertebrates. It forms the musculoskeletal system in humans, along with the skeletal system, and is responsible for body movement.
Muscles control movement and are linked to bones, internal organs, and blood arteries. Muscle contraction causes nearly all movement in the body.
So, B is the right answer.
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The destruction of the fibrin of a blood clot is called __.
fibrinolysis
Answers
The normal disintegration of clots is referred to as primary fibrinolysis. Secondary fibrinolysis is the breakup of blood clots caused by a medical condition, medication, or other factor.
This could result in severe bleeding. Blood clotting usually happens when a blood vessel is damaged. Pay attention to the pronunciation. (throm-BOL-ih-sis) Breaking apart a thrombus (blood clot) that is impeding blood flow. Drugs inserted through a catheter (tube) into the blood clot may dissolve it.
Plasmin degrades fibrin into soluble components known as fibrin degradation products (FDPs). FDPs compete with thrombin and hence limit clot formation by blocking fibrinogen conversion to fibrin.
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define terms organic molecules and inorganic molecules
Answers
Answer:
Organic molecules are molecules that have non-carbon atoms inside them. And, Inorganic molecules are molecules which don't consist of any carbons at all, unlike organic molecules.
Answer: Organic molecules contain carbon particles in them but inorganic molecules have no carbon particles in them
Explanation: In organic molecules they contain a carbon-hydrogen bond mostly found or created in humans or living organisms but inorganic molecules contain none of them.
Organic molecules are molecules which are able to decompose due to what they contain e.g carbohydrates.....
inorganic molecules cant decomposes because they contain no carbon -hydrogen bond.
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Corundum is a mineral with a hardness of 9 on the Mohs hardness scale. For which application would corundum most likely be useful?
Answers
Answer:
grinding media, polishing compounds, sand papers, grinding wheels, and other cutting applications
Explanation:
The asnwer is B. Grinding Glass