Why is it so difficult to control the alkylation of primary amines in an sn2-type reaction manifold? select the best answer.

Answers

Answer 1

The products of the first and second alkylation event are still very active alkylation agents.

What is meant by Amine alkylation?An organic reaction between an alkyl halide and an amine or ammonia is known as amine alkylation (amino-dehalogenation). A higher substituted amine is the reaction's end product, and the reaction is known as nucleophilic aliphatic substitution (of the halide).A tertiary alkyl cation is added to an olefin in a conventional paraffin (alkane)-olefin (alkene) alkylation, which is an acid-catalyzed process. It is produced from an isoalkane (through hydride abstraction). The isobutane-ethylene alkylation reaction, which results in 2,3-dimethylbutane, is an illustration of such a reaction.The term "Friedel-Crafts Alkylation" describes the substitution of an alkyl group for an aromatic proton. This is accomplished by using a carbocation to conduct an electrophilic assault on the aromatic ring. Alkyl halides are used as reactants in the Friedel-Crafts alkylation process, which produces alkylbenzenes.The primary amine produced can also interact with the alkyl halide to produce a disubstituted amine, which can then interact with another substance to produce a trisubstituted amine. Alkylation of ammonia results in a variety of compounds as a result.

Why is it so difficult to control the alkylation of primary amines in an sn2-type reaction manifold?

The products of the first and second alkylation event are still very active alkylation agents.

Primary and secondary formed amines by alkylation have more nucleophilic N (+I of alkyl group) which can further react with alkyl halide to give alkylation. Thus the reaction gives tertiary and quaternary amines.

Explanation:

The alkylation of ammonia during the manufacture of amine prevents the synthesis of secondary and tertiary amine. The Carbyl Amine Test is used to test it.

Because they react with alcoholic KOH, secondary and tertiary amine production fails to pass the carbylamine test.

The carbbylamine test is a test for identifying primary amines.

In this heating, an amine is present while the substance is being heated with chloroform in a basic solution.

It can be detected by the isocyanide's distinctively bad odor.

A positive carbylamine test will be produced by primary amines such isopropyl amine.

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Related Questions

The following properties are either physical or chemical. Which one is different from the rest based on those two category? A.) Density B.) Appearance C.) Color D.) Reactivity

Answers

Answer:

A.)physical B.)physical C.)physical D.)chemical

what hydrogen/signal in the product structure/nmr is strongly indicative that you successfully reduced the imine to the amine?

Answers

When an imine is reduced to an amine, a hydrogen signal is observed in the nuclear magnetic resonance (NMR) spectrum that is indicative of the newly formed amine group.

Specifically, a broad singlet peak is typically observed in the NMR spectrum at around 2-3 ppm, which corresponds to the protons attached to the nitrogen atom in the amine.

This peak is distinct from the peak observed for the protons attached to the carbon atoms in the molecule, which typically appear as sharp peaks at around 0-2 ppm in the NMR spectrum.

Additionally, the chemical shift of the amine proton peak is typically lower than that of the imine proton peak, which is typically observed at around 6-8 ppm in the NMR spectrum.

Therefore, the presence of a broad singlet peak at around 2-3 ppm in the NMR spectrum is strongly indicative that the imine has been successfully reduced to the amine.

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There are three major parts within each dna nucleotide. of these three, which is responsible for the storage of genetic information?

Answers

nitrogen base, pentode sugar, and a phosphate. the storage is within the nitrogen base

Can you pls help me out

Can you pls help me out

Answers

Answer:

A

Explanation:

yellow perch doesn't have a arrow to it from the snail

Scenario: joe cool is a busy student with limited resources. question: what advice would you provide to help him create an exercise program that works within his limitations? what strategies will help him overcome his obstacles?

Answers

Joe Cool create an exercise program that works within his limitations is to focus on the basics and be realistic with his goals. Joe should start with simple exercises that can be done at home or with minimal equipment, such as push-ups, squats, and lunges.

It is important to understand the importance of warming up before exercise and cooling down afterwards. Additionally, incorporating stretching exercises can help to reduce the risk of injury. An explanation for Joe to help him overcome his obstacles would be to prioritize his time and set aside specific times for exercise. He could also consider joining a gym or finding a workout buddy to help motivate him. Additionally, it is important for Joe to remember that consistency is key. Even small amounts of exercise done regularly can provide health benefits.

Bodyweight exercises: These require no equipment, making them affordable and convenient. Examples include push-ups, squats, lunges, and planks. Short but effective workouts: High-intensity interval training (HIIT) and circuit training are examples of time-efficient workouts that can be completed in 20-30 minutes. Incorporate enjoyable activities: Choosing exercises that Joe enjoys, such as dancing or playing a sport, will increase the likelihood that he sticks to the program. Set realistic goals: Start with manageable goals and gradually increase the intensity and duration of workouts as fitness levels improve.
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What do polar bonds share with electrons?

Answers

Answer:

Polar Covalent Bonds. A polar covalent bond exists when atoms with different electronegativities share electrons in a covalent bond. Consider the hydrogen chloride (HCl) molecule. Each atom in HCl requires one more electron to form an inert gas electron configuration.

Explanation:

how do i do this? it doesn’t make sense

 how do i do this? it doesnt make sense

Answers

The charge of phosphate is -3There is 1 phosphate in the compoundThe total negative charge in the compound is -8There is 1 iron in the compoundThe charge of the iron is +3

How to calculate charge?

Phosphate is any salt or ester of phosphoric acid with the chemical formula PO₄³-

According to this question, a chemical compound with the formula; FePO₄ was given. The iron ion has a 3+ charge and the phosphate ion has a 3- charge.

Charge of an ion can be estimated by finding the difference between the number of protons and electrons in the atom.

Phosphate is an ion with charge of -3, hence, it complements an iron ion with charge +3 to form a neutral compound.

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Why do scientist use the scientific method

Why do scientist use the scientific method

Answers

Answer:

B

Explanation:

scientists always look for evidence

Answer:

Yea its B

Explanation: The person above me legit toke the answer out of my mouth

What was one main point of Dalton’s atomic theory

Answers

Answer:

Everything is composed of atoms! which are the indivisible building blocks of matter and cannot be destroyed. All atoms of an element are identical. The atoms of different elements vary in size and mass.

Explanation:

Hope this helped

Answer:

John Dalton in 1808 put forward a theory known as Dalton's atomic theory. The main points of this theory are 1)Matter is made up of extremely small indivisible particles called atoms. 2) Atoms of the same element are identical in all respect i.e. shape, size, and mass.... 8)An atom can neither be created nor destroyed.

Explanation:

what do big differences between mewso (calc) and meweff (experiment) depend on

Answers


The big differences between the mean surface energy (μWSO, calc) and the effective work function (μeff, experiment) depend on various factors. The μWSO is a calculated value, typically obtained through theoretical models and simulations, while μeff is an experimentally measured value.

These differences can depend on:

1. Inaccuracies in the theoretical models: The models used for calculating μWSO might not perfectly capture all the physical processes involved, leading to discrepancies between the calculated and experimental values.

2. Experimental uncertainties: Experimental methods for measuring μeff might have limitations and inaccuracies, which can contribute to the differences observed.

3. Surface irregularities: Real surfaces often have defects, roughness, and contamination, which can affect the measured μeff. These factors might not be considered in the calculations for μWSO.

4. Temperature variations: Differences in temperature between the theoretical calculations and experimental conditions can lead to variations in the measured values.

By addressing these factors and refining both theoretical models and experimental methods, the differences between μWSO and μeff can be minimized, leading to better agreement between calculated and experimental results.

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photoelectron spectroscopy is used to remove one electron from an atom or molecule. this process was used to remove one electron from neon. how many different ionization energy bands were found? (ignore effects from spin).

Answers

According to the electronic configuration, neon has 10 different  ionization energy bands.

What is ionization energy?

Ionization energy is defined as the minimum amount of energy required to remove an electron which is loosely held in the outermost shell to form an isolated gaseous atom,ion or molecule.

It has a positive value for neutral atoms indicating that the ionization process is an endothermic process . The closer the outermost shell electrons are to the nucleus of an atom higher is it's ionization energy.It is expressed in electron volts or joules.

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PLS HELP I WILL GIVE BRAINLISTED AND I GIVE YOU SO MUCH STUFF FI NEED IT PLS

PLS HELP I WILL GIVE BRAINLISTED AND I GIVE YOU SO MUCH STUFF FI NEED IT PLS

Answers

Photosynthesis removes CO2 and animal activities, burning fossil fuels and burning wood add CO2.

Why is CO2 needed?

The main greenhouse gas that helps keep our atmosphere warm is carbon dioxide. Without them, our earth would be uninhabitable. However, the rise in average global temperature due to rising levels of CO2 in our atmosphere is affecting other aspects of Earth's climate. Carbon dioxide is required for the internal respiration of the human body. Internal respiration is the process of removing carbon dioxide and delivering oxygen to body tissues.

The pH value of the blood is protected by the vital carbon dioxide. Therefore, only plants excrete CO2.

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Does fertilizer make a plant grow bigger?mention two variables. How change of one variable effects another one in investigation?

Trick question
Science

Answers

In scientific investigations, the effect of fertilizer on plant growth can be studied by examining various variables. Two key variables in this context are the presence or absence of fertilizer (independent variable) and the size or growth of the plant (dependent variable).

When investigating the effect of fertilizer on plant growth, the independent variable is the presence or absence of fertilizer. This variable is controlled by having two groups of plants: one group receiving fertilizer (experimental group) and another group without fertilizer (control group). By comparing the growth of these two groups, we can determine the impact of fertilizer on plant size.

The dependent variable, on the other hand, is the size or growth of the plant. This variable is measured or observed as the outcome of interest. In this case, it would be the height, weight, or overall size of the plants.

By systematically changing the independent variable (presence or absence of fertilizer), we can observe how it affects the dependent variable (plant growth). The experimental group receiving fertilizer is expected to show greater plant growth compared to the control group without fertilizer. This allows us to draw conclusions about the effect of fertilizer on plant growth.

However, it is important to note that the specific outcome may vary depending on other factors such as plant species, soil conditions, and environmental factors. Conducting a controlled experiment while considering these factors helps in obtaining more reliable results.

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A small airplane takes on 253 L of fuel. If the density of the fuel is 0.821 g/mL , what mass of fuel has the airplane taken on

Answers

This problem is providing the volume and density of a fuel an airplane uses to function, so its mass is required and found to be 208 kg according to the following:

What is the density?

In science, we define density as the degree of compactness of a substance and can be mathematically calculated with:

\(d=\frac{m}{V}\)

Thus, since this problem provides us with the volume and density, one can solve for the mass as shown below:

\(m=d*V\)

Hence, we plug in the given data and convert liters to milliliters in order to have consistent units:

\(m=0.821\frac{g}{mL} *253L*\frac{1000mL}{1L}\\ \\m=207,713g =208 kg\)

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what is the major organic product obtained from the following reaction? question 10 options: 1-butene, ch3ch2ch

Answers

The major organic product obtained from the reaction of 1-butene with HCl is CH3CH2CH2Cl.

The reaction is an example of a substitution reaction, where a hydrogen atom of the alkene is replaced by a chlorine atom. This is known as an "E2" reaction (Elimination - bimolecular).
The reaction proceeds with a "Backside Attack" by the chlorine atom. This attack is facilitated by the electron-withdrawing effect of the chloride ion, which polarizes the double bond and allows the chlorine atom to attack the less substituted carbon atom.

Attack from the Backside: During a backside attack, the nucleophile targets the electrophilic centre on the side that is opposite the departing group. The product's stereochemistry changes when a backside assault takes place. There is configuration inversion.

The result is the formation of a secondary halide, CH3CH2CH2Cl.

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which best describes a solution that is a good conductor of electricity and turns blue litmus paper red? which best describes a solution that is a good conductor of electricity and turns blue litmus paper red? strong acid weak base weak acid strong base\

Answers

Answer: acidic solutions will turn litmus paper red; and an alkaline solution will turn litmus paper blue.

Explanation: Litmus paper is red when the pH is less than 4.5 and blue when the pH is greater than 8.3.

also frogs are great

What is the name of this compound CH3CH(CH3)CH3

Answers

The Correct option is A, The IUPAC name of the compound CH3–CHCH3–CO–CH3 is 3-methyl-2-butanone.

In chemistry, a compound is a substance formed by the chemical combination of two or more different elements in fixed proportions. The atoms in a compound are held together by chemical bonds, which can be covalent, ionic, or metallic depending on the nature of the elements involved.

Compounds have unique physical and chemical properties that are different from their constituent elements. For example, water is a compound formed by the chemical combination of hydrogen and oxygen in a fixed ratio of 2:1 by mass. While hydrogen is a highly flammable gas and oxygen is necessary for combustion, water is a non-flammable liquid that is essential for life.

There are many different types of compounds, including organic and inorganic compounds. Organic compounds are those that contain carbon atoms, while inorganic compounds do not. Examples of organic compounds include sugars, proteins, and fats, while examples of inorganic compounds include salt, water, and carbon dioxide.

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Complete Question:

The IUPAC name of the compound CH3–CHCH3–CO–CH3 is

A 3-methyl-2-butanone

B 2-methyl-3-butanone

C Isopropyl methyl ketone

D 2ethyl-2methyl pentane

why is the conjugate acid of alkoxide used as solvent for williamson ether synthesis

Answers

The conjugate acid of alkoxide is used as a solvent for Williamson ether synthesis. This is because the conjugate acid of alkoxide, which is an alcohol, is a polar, aprotic solvent, which means it has high solubility, a low nucleophilicity, and low reactivity with the substrate, which leads to fewer side reactions.

Williamson ether synthesis is a reaction in which an alkoxide reacts with an alkyl halide to form an ether. The reaction takes place in the presence of a strong base. The alkoxide ion acts as a nucleophile and attacks the electrophilic carbon in the alkyl halide. The reaction forms an ether and a salt, which is neutralized by a proton from the solvent. The solvent is usually an alcohol, which can act as a base and form the conjugate acid of the alkoxide ion. The conjugate acid of the alkoxide ion is a polar, aprotic solvent, which means it is a good solvent for the reaction.

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5. Density can be used to determine the purity of a substance like gold

A True

B. False

C. Not enough information

D. Cannot tell

Answers

Answer:True

Explanation:

If a substance is pure, it will have exactly the same density as that reported for that particular substance in standard literature or vary within very narrow limits. Hence we can determine the purity of a gold sample by measuring it's density.

calculate the moles of ammonia present in a 6.364 g sample of ammonia, which has a molar mass of 17.030 g/mol.

Answers

The moles of ammonia present in a 6.364 g sample of ammonia are 0.373 moles.

The number of moles(n) are the ratio of mass(m) to the molar mass(M). Mole is the unit of amount in chemistry. It is SI unit and represented by "mol". It is expressed as follows-

n= m/M

The given parameters are-

m=6.364 g

M= 17.030 g/mol

The number of moles can be calculated as follows-

n= 6.364/ 17.030

 =0.373

Thus, the number of moles of ammonia are 0.373 moles.

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easy ones! giving brainly if correct. answering both questions would be nice​

easy ones! giving brainly if correct. answering both questions would be nice

Answers

Answer:

All of the above

Explanation:

temperature, nature of solvent and solute, surface area , pressure ,  amount of stirring affect rate of dissolving.

the above answer will be liquid

Bleach boils at 101°C. Isopropyl alcohol (rubbing alcohol) boils at 82.5°C. Vinegar boils at 100.6°C. Water boils at 100°C. A student has an unknown clear liquid. She wants to determine what it is, so she decides to boil the liquid and use the boiling point as a means of identification. The liquid starts boiling at 99°C. Based on the boiling points shown, which substance is it?

Answers

Answer:

most likely water

Explanation:

most likely it is water, however pressure plays a role, if you are at sea level the boiling point of water is 100°C but if you are on Mt. Everest it is 71°C, assuming she is slightly above sea level it is water.

Which of the following is the smaller atom: magnesium or chlorine?

Answers

Answer:

Chlorine atoms are smaller

Explanation:

Magnesium have more electrons than chlorine.

Answer: Chlorine

Explanation: Since chlorine's 17 protons are greater than magnesium's 12 protons, chlorine will have a greater effective nuclear charge to draw chlorine's valence electrons closer to the nucleus and, thus, chlorine is expected to have the smaller atomic radius, while magnesium with the lower effective nuclear charge is expected to have the larger atomic radius.

     

Cordell bought new tires for his bicycle. As he rode his bike on the hot street, the temperature of the air in the tires increased. If the volume of the air stayed the same, what happened to the pressure inside the tires?
A. It decreased. B. It increased. C. It stayed the same. D. It was inversely proportional to the temperature

Answers

Answer: The answer is B. The pressure inside the tires increased.

Explanation:

The relationship between the pressure, volume, and temperature of a gas is described by the ideal gas law, which is usually written as:

\($$PV = nRT$$\)

where:

- \(\(P\)\) is the pressure,

- \(\(V\)\) is the volume,

- \(\(n\)\) is the number of moles of gas,

- \(\(R\)\) is the ideal gas constant, and

- \(\(T\)\) is the temperature (in Kelvin).

In this case, the volume \(\(V\)\) and the number of moles \(\(n\)\) of air in the tires stay the same. The temperature \(\(T\)\) is increasing. Therefore, for the equation to remain balanced, the pressure \(\(P\)\) must also increase.

So, the answer is B. The pressure inside the tires increased.

Why can't an atom lose or gain a proton?

Answers

When an atom loses or gains a proton the atomic number is changed making it change what element it is.

what is the use of ovulation?​

Answers

Ovulation is the process in which mature egg is released from ovary.

What is Ovulation ?

The process in which a mature egg is released from ovary is known as Ovulation. It occurs as a LH (Luteinizing hormone) surge. Ovulation process occurs every month. In the ovulation process the ovum enters in the fallopian tube.

A menstrual cycle is divided into four phase:

Menstrual phaseFollicular PhaseOvulatory Phase Luteal Phase

Thus from the above conclusion we can say that Ovulation is the process in which mature egg is released from ovary.  

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structural isomers can have drastically different roles in the body. furthermore, only one of multiple optical isomers may be made by the body or be useful as a therapeutic agent. how many structural isomers of c3h6br2 are capable of exhibiting optical activity?

Answers

Structural isomers are molecules that have the same chemical formula, but a different arrangement of atoms. These different arrangements can lead to molecules that have vastly different properties, such as different boiling points, melting points, and reactivity. In the case of C3H6Br2, there are two structural isomers: 1,2-dibromoethane and 1,2-dibromopropane.

Optical isomers, also known as enantiomers, are specific types of structural isomers that can rotate plane-polarized light in opposite directions. These enantiomers are mirror images of each other and are non-superimposable.

1,2-dibromoethane has a chiral centre which is an asymmetric carbon atom that can exist as two enantiomers (Mirror images). So, 1,2-dibromoethane is capable of exhibiting optical activity. However, 1,2-dibromopropane does not have a chiral centre and therefore cannot exist as enantiomers and cannot exhibit optical activity.

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A solution can only br made from the same amounts of solute and solvent

Answers

The statement that a solution can only be made from the same amounts of solute and solvent is not entirely accurate. While it is true that certain solutions may require a specific ratio of solute to solvent for optimal results, the concentration of a solution can vary depending on the desired outcome.

For example, a dilute solution may contain a small amount of solute relative to the amount of solvent, whereas a concentrated solution may contain a larger amount of solute in the same amount of solvent.

Additionally, the solubility of a solute can also affect the amount of solute needed to form a solution. Some solutes may have a higher solubility in a given solvent than others, meaning that less of that solute is needed to create a saturated solution.

Overall, while a certain amount of solute and solvent may be needed to form a solution, the concentration and solubility of the solute can vary and ultimately affect the amount needed to create a specific solution.

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the free energy associated with a pair of electrons (e-) carried by fadh2 is lower than those carried by nadh because

Answers

The reason why the free energy associated with a pair of electrons (e-) carried by FADH₂ is lower than that of those carried by NADH is due to the different redox potentials of the two electron carriers.

The free energy associated with a pair of electrons (e-) carried by  FADH₂  is lower than those carried by NADH because FADH₂  donates its electrons to the electron transport chain at a later stage than NADH. During cellular respiration, both NADH and FADH₂ donate electrons to the electron transport chain, which generates a proton gradient across the inner mitochondrial membrane. This gradient is used by ATP synthase to generate ATP.

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What is a neutralization reaction?
O A. A reaction in which the product is either acidic or basic
O B. A reaction that involves neutral reactants
O c. A reaction in which the reactants are a salt and water
O D. A reaction that removes essentially all Ht and OH

Answers

The answer is D. A reaction that removes essentially all H+ and OH-

Answer:

D or A your choice

Explanation:

uhhh didnt u- nvm

A neutralization reaction is when an acid and a base react to form water and a salt and involves the combination of H+ ions and OH- ions to generate wate

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