sickle cell disease mutation, pathophysiology, crisis symptoms

--sickle cell is due to a point mutation in 6th codon of beta chains causing substitution of glutamate with valine
--sudden fever, severe rib pain or local pain, tenderness, sickle cells on peripheral blood smear
--sickle cell Hb polymerizes under hypoxic conditions due to amino acid substitution on beta chain

Answers

Answer 1

Sickle cell disease is caused by a point mutation in the 6th codon of the beta-globin chains, leading to the substitution of glutamic acid with valine.

This mutation results in abnormal hemoglobin, called hemoglobin S (HbS), which causes red blood cells to assume a sickle shape under hypoxic conditions. The pathophysiology of sickle cell disease is centered around the polymerization of HbS under low oxygen levels. The sickle-shaped red blood cells are less flexible and more prone to clumping, leading to vaso-occlusive events, ischemia, and tissue damage. Furthermore, these abnormal cells have a shorter lifespan, contributing to hemolytic anemia.

Crisis symptoms in sickle cell disease can manifest as sudden fever, severe localized pain, and tenderness, often in the chest or ribs. These symptoms result from vaso-occlusion and subsequent tissue ischemia. A peripheral blood smear may reveal the presence of sickle cells, confirming the diagnosis. Proper management of sickle cell crisis typically involves pain relief, hydration, and oxygen therapy to mitigate hypoxia and alleviate symptoms.

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Related Questions

the_layer of the skin helps regulate our body temperature​

Answers

Answer:

Dermis

Explanation:

the sweat glands of the dermis secrete sweat, which then evaporates on the surface of the skin.

the DERMIS layer of the skin helps regulate our body temperature

Toxic effects are a function of several factors except:
A. Route of entry B. Time of day C. Level of exposure D. Amount of dose

Answers

The correct answer is B. Time of day.

Toxic effects are indeed a function of several factors such as the route of entry (how the substance enters the body), the level of exposure (the concentration and duration of exposure to the substance), and the amount of dose (the quantity of the substance administered). However, the time of day is not typically a factor that directly influences toxic effects.

Too much cholesterol is a bad thing, but your body needs some cholesterol to work. What is the function of cholesterol in your body?

Answers

Answer:

One function of cholesterol in the body is better digestion. Without cholesterol, the body could not digest fat. When a person consumes food that contains fat, the gallbladder releases bile which breaks down large chunks of fat into much smaller particles that can be effectively digested by the body.

Explanation:

plz vote brainlyest

4. Mrs. Robins states that she should not have her blood pressure taken on her left arm
because she has had a mastectomy. She indicates that her lymph nodes were also removed on
that side and the doctor told her not to have her blood pressure taken on that side. Why would a
doctor say this? You may need to refer to the Internet for the reason why

Answers

Answer:

Its precautionary to prevent lymphedema.

Explanation:

Sometimes, removing lymph nodes can make it hard for your lymphatic system to drain properly. If this happens, lymphatic fluid can build up in the area where the lymph nodes were removed. This extra fluid causes swelling called lymphedema.

The surgical partial or total removal of one or both breasts is referred to medically as a mastectomy. Breast cancer is typically treated with a mastectomy. Women who are thought to have a high risk of developing breast cancer occasionally have the procedure done as a preventative step.

What is Lymphedema?Lymphedema is caused by a blockage in the lymphatic system. This is usually the result of a traumatic event, such as a sports injury or deep cuts and bruises, or as a side effect of surgery or cancer treatment. Lymphedema can occur as a birth defect or as a symptom of infection in rare cases. Precautions are required to prevent lymphedema. When lymph nodes are removed, your lymphatic system may struggle to discharge properly on occasion. If this occurs, lymphatic fluid may accumulate where the lymph nodes were removed. Lymphedema is a swelling caused by extra fluid. It is critical to understand that lymphedema can sometimes become severe and cause serious problems, and that it is frequently a long-term or chronic condition.

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In the context of survey research, identify a true statement about a sample.

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The sample simply means the set of individuals that are selected from the total population by the researcher.

A survey research refers to the quantitative method that's used by researchers when they want to collect information from respondents

A survey simply means the list of questions that are given to the respondents in order to get a specific data from them which will be used for a research purpose

A sample simply means part of a larger group. The smaller represents the whole group. For example, if there are 100 students in a class, a researcher can choose 10 students from the 100 students. The 10 students chosen represent the sample.

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health records management

Answers

Health records management refers to the process of collecting, organizing, and maintaining healthcare-related information for patients.

What is Health records management?

Health records management is important for several reasons, including:

Providing a comprehensive view of a patient's health history, which can help healthcare providers make informed decisions about diagnosis and treatment.

Ensuring accuracy and completeness of patient information, which is critical for effective healthcare delivery and patient safety.

Supporting communication and collaboration among healthcare providers, which can improve care coordination and patient outcomes.

Meeting legal and regulatory requirements for maintaining patient records, including privacy and security standards.

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a condition that affects the lungs is called...
A. cardiac, asthma
B. respiratory, diabetes
C. respiratory, asthma
D. cardiac, heart disease ​

Answers

Answer:

C

Explanation:

All the other things have things that are cardiac...cardiac is heart

Answer:

C. respiratory, asthma

Explanation:

Cardiac refers to the heart, diabetes is an endocrine disease, heart disease is, well, a disease of the heart.

Asthma is an example of a lung condition, and respiratory refers to the lungs.

which of the following medications is indicated to treat benign prostatic hyperplasia? flonase, flomax, fosamax, folic acid

Answers

The medication indicated to treat benign prostatic hyperplasia (BPH) among the options provided is Flomax (generic name: tamsulosin).

Flonase (fluticasone) is a nasal spray commonly used to treat allergic rhinitis or nasal congestion due to allergies. It is not indicated for the treatment of BPH.

Fosamax (alendronate) is a medication used to treat and prevent osteoporosis. It is not indicated for the treatment of BPH.

Folic acid is a B vitamin that is commonly used as a supplement, particularly during pregnancy or for individuals with certain nutritional deficiencies. It is not indicated for the treatment of BPH.

Flomax (tamsulosin) is an alpha-blocker medication specifically approved for the treatment of BPH. It works by relaxing the muscles in the prostate and bladder neck, improving urine flow and reducing symptoms associated with BPH, such as frequent urination, difficulty in starting and maintaining urine flow, and urinary urgency.

Therefore, the correct answer is Flomax (tamsulosin).

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the nurse is working with a group of caregivers of school-aged children discussing fractures. the nurse explains that if the fragments of fractured bone are separated, the fracture is said to be:

Answers

If the bone fragments are separated, we can say that a complete fracture has occurred.

What is a complete fracture?It is the fracture that completely breaks the bone structure.It is the fracture that disconnects the parts of the bone.

The complete fracture can occur in several ways that are classified according to the breakage of the bone fragments and the angle formed between these fragments. In this case, the complete fracture may be called a transverse fracture, oblique fracture, and spiral fracture.

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for Influenza what is clinical intervention (remember timeframe for antivirals)

Answers

Antiviral medications should be given within the first 48 hours of symptoms onset to reduce the duration and severity of influenza.

Clinical intervention for influenza includes prompt antiviral treatment within 48 hours of symptom onset for high-risk patients, including those with severe or progressive illness, those hospitalized with suspected or confirmed influenza, and those at high risk for complications (e.g., young children, elderly, immunocompromised individuals). Antiviral medications like oseltamivir, zanamivir, or peramivir can be used for the treatment of influenza. These drugs can reduce the duration and severity of the illness, prevent complications, and decrease the risk of hospitalization and death. Other interventions may include symptom management, such as rest, hydration, fever control, and the prevention of secondary bacterial infections. Vaccination is also an important measure for the prevention of influenza.

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cheggg how can the themes in this story be applied to a position in healthcare? what’s important in the ""take away"" regarding empathy in medicine?

Answers

The themes in this story of empathy in medicine can be applied to a position in healthcare by teaching healthcare providers to be more understanding, patient and compassionate to their patients.

It is essential to remember that the patient is more than just their diagnosis and to take the time to get to know them as an individual. The most important takeaway from this story is that showing empathy and compassion to patient’s can often have a positive effect on the patient’s health outcomes.

In doing so, healthcare providers should strive to make the patient feel heard and respected, take the time to listen and understand their perspective, and treat them with kindness and compassion. Empathy should be an integral part of healthcare and should be a priority for healthcare providers.

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cell membranes are not fully permeable

Answers

Answer:

They are semi permeable

Explanation:

Mean that some molecules can diffuse across the lipids bilayer but other cannot.

This statement is true. Cell membranes exhibit two principles called selective permeability and semi-permeability, often incorrectly used interchangeably! The first means that the composition of the cell membrane allows for some specific molecules to perfuse into and out of the cell while disallowing other specific molecules, depending on certain cellular conditions, properties, functions, and metabolic activity. If the cytoplasm is a party, the cell membrane is the security guard that checks the list and either bounces guests or lets them pass the stanchion. The second means that the membrane distinguishes which molecules can pass according to their size, electrical charge, solubility, and other properties (chemical or physical) that fit or do not fit the cell's needs.

which action can best limit the transmission of pathogens by indirect contact

Answers

Answer:  To wash your hands regularly with soap and water.

Explanation: Indirect transmission occurs when one person touches something, like this doorknob, leaving behind germs. When another person touches it, they pick up some of the germs.

Answer:

Washing vegetables

Explanation:

dr. yep is conducting a randomized control trial examining whether zeppo, a newly developed anxiety medication, is effective for reducing anxiety. in this study, the treatment group will be given

Answers

Answer:

the new drug, Zeppo.

Explanation:

In the study, the treatment group will be given the new drug Zippo.

What is drug?

Drug is defined as any chemical that, when taken, alters the physiology or psychology of an organism. Drugs have an impact on how neurons send, receive, and process signals using neurotransmitters. Because some drugs, like heroin and marijuana, have molecular structures that are similar to those of natural neurotransmitters in the body, they can activate neurons.

Symptoms of an anxiety disorder include feelings of unease, panic, and fear. Physical signs like sweating and a fast heartbeat may also be present. Antidepressants, which include medications from the selective serotonin reuptake inhibitor (SSRI) and serotonin and norepinephrine reuptake inhibitor (SNRI) groups, are the first-line pharmacological therapy.

Thus, in the study, the treatment group will be given the new drug Zippo.

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Psychodynamic perspective of treatment puts a focus on

Answers

Answer: Psychodynamic therapy focuses on unconscious processes as they are manifested in the client's present behavior. The goals of psychodynamic therapy are client self-awareness and understanding of the influence of the past on present behavior.

Explanation: i took test

A compound drug related to both amphetamines and hallucinogens is called
A. marijuana
B. LSD
C. morphine
D. MDMA (ecstasy)

Answers

The answer should be c
It would be “c”!!!!!!!

A 25- year- old female has come to the clinic with the complaints of irritability, diarrhea with a swelling in front of the neck for the past 1 month.

Q1. List FOUR relevant questions you will ask in history in this patient.

Answers

Answer:

why my neck is penning, give me a medicine for diarrhea and heck ache

1. What medications are you taking?
2. Do you have any previous history of diarrhea?
3.Has anything changed within your eating habits?
4. Are you feeling pain in the area of swelling?

Imagina que tocas algo muy áspero que te resulta muy doloroso que información envías a tu cerebro ? Qué respuesta crees que dará tu cerebro a esta situación?

Answers

If you are very hopeful that you will be very painful, the pain receptors in your skin will send electrical signals through your nerves to your spinal cord and then to your brain to inform it of your painful experience.

This information will be processed by the brain, which will produce an immediate response of withdrawing the awaiting object's hand. Furthermore, the brain will send signals to activate the sympathetic nervous system, increasing cardiac frequency and arterial pressure, and releasing hormones such as adrenalin to prepare the body to respond to a dangerous situation.

To summarize, when you experience pain, your brain receives signals from your nerves and responds with an immediate response to protect your body from harm.

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Translated Question ;

Consider that you are very hopeful that information is being sent to your brain. What response do you think your mind will give to this situation?

a nurse is assisting with the removal a of central venous access device (cvad). the nurse should:

Answers

When a nurse is assisting with the removal of a central venous access device (CVAD), they should follow proper protocol to ensure patient safety and prevent infection. This includes using sterile technique, wearing gloves, applying pressure to the site after removal to prevent bleeding, and monitoring for any signs of complications.

              The nurse assisting with the removal of a central venous access device (CVAD) should ensure that the patient is in a comfortable position and provide local anesthesia if necessary. The nurse should also follow sterile technique, carefully removing the dressing and disconnecting the CVAD from any tubing or lines. Once the device is removed, the nurse should apply pressure to the insertion site to prevent bleeding and observe for any signs of complications. Finally, the nurse should document the removal of the CVAD in the patient's medical record.

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A. _____ can contaminate raw produce; can cause damage to the liver. B. _____ outbreaks have been associated with raw or undercooked eggs and undercooked poultry; can be prevented by thoroughly cooking foods. C. _____ found in the intestinal tracts of cattle; outbreaks have been linked with raw and undercooked ground beef and fresh produce; can be prevented by thoroughly cooking meat. D. _____ found in soil and water; outbreaks have been traced to untreated garlic-and-oil products and improperly canned foods. E. _____ illness from this pathogen can cause diarrhea, nausea, and vomiting; found in contaminated water.

Answers

Answer:

(A) Hepatitis

(B) Salmonella/Salmonellosis

(C)E-Coil

(D) Botulism

(E)Norovirus

Explanation:

And the explanation is already written above

So, identifying the diseases from their description, we associate them as:

(A) Hepatitis

(B) Salmonella/Salmonellosis

(C)E-Coil

(D) Botulism

(E)Norovirus

What diseases can you get from contaminated food?

Making the association and defining each of the diseases, we have that:

Hepatitis can contaminate raw produce; can cause damage to the liver;Salmonella/Salmonellosis outbreaks have been associated with raw or undercooked eggs and undercooked poultry; can be prevented by thoroughly cooking foods;E-Coil found in the intestinal tracts of cattle; outbreaks have been linked with raw and undercooked ground beef and fresh produce; can be prevented by thoroughly cooking meat;Botulism found in soil and water; outbreaks have been traced to untreated garlic-and-oil products and improperly canned foods;Norovirus illness from this pathogen can cause diarrhea, nausea, and vomiting; found in contaminated water;

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Which of the following foods has the lowest percentage of water?
A. Almonds
B. Peaches
C. Cucumbers
D. Lettuce

Answers

Among the given options, almonds have the lowest percentage of water. Almonds typically contain a much lower water content compared to peaches, cucumbers, and lettuce.

Water content in foods can vary significantly depending on their composition. Almonds are known for having a relatively low water content. On average, almonds contain around 4% water, making them a food item with a low percentage of water. Peaches, on the other hand, have a higher water content, typically ranging from 80% to 90%. Cucumbers are composed of approximately 96% water, while lettuce is composed of about 95% water. Hence, when comparing the options provided, almonds have the lowest percentage of water among them.

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You arrive at the scene of a domestic violence situation. As you approach the doorway of the apartment, you hear screaming and the statement "He has a gun!" Your MOST appropriate action should be to: ____.

Answers

Seek a safe place and request law enforcement assistance.

Domestic violence is defined as violence committed by someone in the victim's immediate family. Partners and ex-partners, immediate family members, other relatives, and family friends are all included. When there is a close relationship between the offender and the victim, the term "domestic violence" is used.

Domestic violence is defined as any act of harm, injury to health, safety, life, limb, or well-being, or any other act of threatening or coercion, etc., committed by any adult member of the family. Any woman who is or has been in a domestic or family relationship who is subjected to any act of domestic violence may file a complaint.

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How can you advocate for patients with autism when certain resources are not available for them in your place of employment?

Answers

Answer:There are specific steps in the advocacy process that you can learn and that will help you be ... a prospective employer to hire him or requesting a particular change or ... They were jammed with filling out insurance forms, keeping the patient flow moving.

Explanation:

True or false. A 12 yearold boy and a 25-year-old girl probably have the same recommended daily intakes of each food group

Answers

The answer is false.
False.

Kids and Adults each have very different food intakes. As the kid can eat less he could choose foods that fill him up faster than the regular adult

The emergency, cardiology, labor and delivery, neurology, and intensive care units are some of the ________ of a typical hospital.

Answers

The answer would be subsystems
Hope this helps:)

The emergency, cardiology, labor and delivery, neurology, and intensive care units are some of the departments of a typical hospital.

A hospital is a type of medical facility that offers a variety of healthcare services to people with different illnesses and injuries. It is a location where patients can access healthcare, get diagnosed, treated, and cared for by licenced healthcare professionals. Hospitals are essential elements of any healthcare system because they provide cutting-edge medical equipment, trained medical personnel, and numerous specialised divisions to meet diverse medical demands. These divisions could be maternity wards, intensive care units, surgical units, radiology departments, and many others.

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A nurse is preparing to administer vancomycin 500 mg by intermittent IV infusion every 6 hr. Available is vancomycin 500 mg in 0.9% sodium chloride 100 mL to infuse over 2 hr. The nurse should set the IV pump to deliver how many mL/hr?

Answers

Vancomycin is an antibiotic medication used for bacterial infections. A 500 mg vancomycin dose can be injected through the IV and should be set to deliver 50 mL/hour.  

What is vancomycin?

Vancomycin is a drug used to treat infections are administered intravenously. It is an antibiotic and works efficiently against bacteria.

Given,

Ordered dose of vancomycin = 500 mg

The available dose is 500 mg in 100 mL

Time = 2 hours

The flow rate of vancomycin is given as,

Flow rate = total ml ÷ time

= 100 mL ÷ 2 hour

= 50 mL/hour

Therefore, the nurse should set the IV pump to deliver the drug at 50 mL/hour.

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Which of the following may be a source of ignition when rescuing people who are trapped in a car that has stopped off the roadway in a field of dried​ grass?
catalytic converter

Answers

When saving people who are stuck in a car that has stopped off the road in a field of dried grass, the catalytic converter can be a source of ignition.

What functions do catalytic converters have?

In essence, a catalytic converter filters out and burns hazardous byproducts found in exhaust gases. Additionally, a catalytic converter not only reduces hazardous emissions but also increases car's efficiency.

Part of the exhaust system are catalytic converters. They are often closer to the engine and are situated between the engine and the muffler. This enables them to swiftly warm up to the high temperatures where they are most useful.

Catalytic converters are standard equipment on all contemporary internal combustion engines. Very old autos lack catalytic converters because they have been needed on new cars since 1975. Since electric cars lack an exhaust system, they don't require a catalytic converter.

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who is a first aider with detailed meaning​

Answers

Answer: Someone in an organization who has been trained to give immediate medical help in an emergency.

Explanation:

What general tissue type binds, supports, and protects the body?.

Answers

Answer :-connective tissue, as it's name implies, binds the cells and organs of the body together and function in the protection, support, and integration of all parts of the body.

Please mark may be brainliest answer.

The nurse is educating an adult client diagnosed with a nonproductive cough about the prescribed dextromethorphan. Which statement made by the client establishes the need for further clarification? "If I raise mucous, I will stop taking the drug and call my prescriber." "I will not eat or drink for 30 minutes after taking a dose." "I will dilute the drug syrup with an equal amount of water." "The drug should only be taken as directed on the package." "I will dilute the drug syrup with an equal amount of water."

Answers

In response to the student's question, the about Dextromethorphan statement that requires further clarification is "I will dilute the drug syrup with an equal amount of water."  

Educating the client diagnosed with a nonproductive cough about the prescribed dextromethorphan. It is important to take the medicine exactly as prescribed by the prescriber. The patient should not consume food or drink for 30 minutes after taking the drug. This would make sure that the medicine is fully absorbed by the body in order to take full effect.

If the cough is productive, do not use this medication because it stops the cough reflex from functioning properly. A client must avoid taking an overdose because it may cause significant side effects, so he must take the medication as prescribed. The client should also call the prescriber right away if he experiences any unusual side effects or symptoms, such as rash or confusion.

If a client fails to follow the instruction, it would not be effective to cure the cough or treat the underlying cause. In addition, it may have negative consequences on the individual's health, worsening the disease or the symptoms.

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If tan > 0, which of the following is true? (1) Sin must be negative. (2) Cos must be negative. (3) must be in Quadrant I. (4) Sin may be positive or negative. which two numbers in this quotient of 88 divided by 5 which of the following elements of the committee of sponsoring organizations refers to policies and procedures that support the cultural issues such as integrity, ethical values, competence, philosophy, and operating style? multiple choice ongoing monitoring risk assessment control environment information and communications Coach salinas wants to compare the kicking statistics for kickers on their team. Which 222 ways could coach salinas find the kicker with the greatest goal success rate? choose 2 answers: choose 2 answers:. Tell whether the relationship shown in the mapping diagram is a function or not. y -2 0 5 1 2 Answer: yes Answer this. Show your work. Worth 15 points. Under 1 day. URGENT. Solve the proportion Round as necessary to the nearest tenth When considering the future, it is useful to remember that: Ellla and some friends are going to a movie. Each movie ticket cost 5 dollars. Create an a equation that shows the relationship between how many friends, n , attend the movie and the total cost in dollars, c. The principal-agent problem that exists for bank trading activities can be reduced through:A) creation of internal controls that combine trading activities with bookkeeping.B) creation of internal controls that separate trading activities from bookkeeping.C) elimination of regulation of banking.D) elimination of internal controls. Which way is counterclockwise?A. The way the hands move on a clock. (To the right)B. The opposite way the hands move on a clock. (To the left) Fixism compared to evolution List (from class material, the 3 focus points of economic studies. Describe (based on your own understanding) those 3 focus points. 1. ABC Det PIDENTIFY THE FINAL BATTLE OF THEREVOLUTION AND EXPLAIN THE EVENTSTHAT LED TO THE BRITISH SURRENDER. If a 100 resistor is placed across a 0. 10 f charged capacitor which is initially charged to 3 v. How long does it take it to discharge to 2v to 1v? Which factor is greater 2/5 or 2/3 how can you tell which fraction is larger (looking for the explanation ) 4. In 1787, U.S. leaders met to create a new government and to write the U.S. Constitution. The Constitutional Convention featured many debates, including one over how much power the federal government should have. a. In two to three sentences, describe the debate over the power of the federal government versus the power of state governments. b. In two to three sentences, describe the delegates' compromise. What was the system of government they created? Determine the following: 4.1. the value of Q at Node D. 4.2. State the basic hydraulic criteria 4.3. the correct flows in each pipes after two iterations. [ Assume initial QAB=80 L/s]. Ignore all minor losses. Assume rho=1000 kg/m3 and =1.002 kg/m.s. Pipe network is given bellow (Figure 2). All pipes are 1 km long, 500 mm in diameter and Hazen-Williams Coefficient of 100. actually give you 20 points if you can solve this correctly and give you brainless and under 20 minutes PLS HELP IM TIMEDShelby wants to buy 10 yards of fabric that costs $2.49 per yard. How much money will Shelby need to purchase all the fabric? $2.49 $4.01 $12.49 $24.90