Asparagine has pKa1 = 2.02 and pKa2 = 8.80. Use the Henderson-Hasselbalch equation to calculate the ratio neutral form/protonated form at pH = 1.82.
Calculate the ratio, deprotonated form/neutral form, at pH = 9.25

Answers

Answer 1

The ratio of the deprotonated form to the neutral form of asparagine at pH 9.25 is 3.16.

The Henderson-Hasselbalch equation relates the pH of a solution to the ratio of the concentrations of a weak acid and its conjugate base, and is given by:

pH = pKa + log([A⁻]/[HA])

where [A⁻] is the concentration of the conjugate base and [HA] is the concentration of the weak acid.

Using this equation, we can calculate the ratio of the neutral form to the protonated form of asparagine at pH 1.82 as follows:

pH = pKa1 + log([A⁻]/[HA])

1.82 = 2.02 + log([A⁻]/[HA])

-0.20 = log([A⁻]/[HA])

0.63 = [A⁻]/[HA]

Therefore, the ratio of the neutral form to the protonated form of asparagine at pH 1.82 is 0.63.

Similarly, we can calculate the ratio of the deprotonated form to the neutral form of asparagine at pH 9.25 as follows:

pH = pKa2 + log([A⁻]/[HA])

9.25 = 8.80 + log([A⁻]/[HA])

0.45 = log([A⁻]/[HA])

3.16 = [A⁻]/[HA]

Therefore, the ratio of the deprotonated form to the neutral form of asparagine at pH 9.25 is 3.16.

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Related Questions

6HCl + 1Fe2O3 = 2FeCl3 + 3H2O

How many moles of Fe2O3 does it take to completely react with 4 moles of HCl?

Answers

Answer: 2/3

Explanation:

6HCl + 1Fe2O3 = 2FeCl3+ 3H2OHow many moles of Fe2O3does it take to completely react with 4 moles of HCl?

b) How does electron gain enthalpy change along a period and in a group?​

Answers

Answer:

Electron gain enthalpy becomes more and more negative from left to right in a period. As we move across a period from left to right the atomic size decreases and the nuclear charge increases

Answer: Variation in electron gain enthalpy in the period : in the modern periodic table, on moving from left to right across a period the atomic size of elements decreases and the effective nuclear charge increases.

hope it helps you

Explanation:

Some pure calcium carbonate is made to react completely with 100cm3 Hydrochloric acid of unknown concentration. 120cm3 of carbon dioxide was formed at Room temperature. calculate the number of moles of carbon dioxide formed at room temperature​

Answers

Answer:

Explanation:

as we know that 1dm3 =1000cm3

therefore x dm3 =120 cm3

1000X =1*120

X dm3 =120/1000=0.12

so 120 cm3 =0.12 dm3

now the number of moles of carbon dioxide at RTP is

moles =given volume(dm3)/standard volume at RTP

moles=0.12dm3/24

moles =5*10^-3

the ____ particles of an atom which are called electrons

Answers

Answer:

Subatomic particles

Explanation:

I hope it helped

Lab: Limiting Reactant and Percent Yield
Student Guide
Pre-Lab Information
Purpose Explore the yield of a chemical reaction by identifying the limiting reactant, comparing the
theoretical and actual yields, and explaining the sources of error.
Time Approximately 45 minutes
Question While observing a chemical reaction, how can you tell which reactant is limiting?
Reaction The reaction of copper(II) chloride and aluminum is shown in this balanced equation:
3CuCl2 + 2Al  2AlCl3 + 3Cu
Hypothesis If a substance is the limiting reactant, then it will be fully consumed by the time the
reaction completes because it is the reactant that reacts completely and the reaction
cannot proceed further.
Summary You will react copper(II) chloride with different quantities of aluminum in two trials. You
will also calculate percent yield for Trial 2.

Answers

Answer:

pre lab information would be the thing you to ressearch the lab to get the information

Limiting Reactant and Percent Yield Lab Report attached

Question III A+ 2B is elementary reversible gas phase reaction that is conducted at 540 °F and 3 atm in a PFR. The feed rate is 75 lb mol/h with 40% A and 60% inert material in the feed. The specific reaction rate k = 1.6 s and the concentration equilibrium constant K = 0.0055 lb mol/ft³. Calculate volume of reactor and space-time if 75 % equilibrium conversion is achieved.

Answers

To calculate the volume of the reactor and space-time for a reversible gas phase reaction, A+2B, conducted at 540 °F and 3 atm with a feed rate of 75 lb mol/h and 40% A, and an equilibrium conversion of 75%, we need to consider the specific reaction rate and the concentration equilibrium constant.

The space-time for a reactor is defined as the volume of the reactor divided by the feed rate. To calculate the volume of the reactor, we first determine the molar flow rate of component A, which is 75 lb mol/h * 0.40 = 30 lb mol/h. Then, we divide the molar flow rate of A by the specific reaction rate to obtain the volume: Volume = 30 lb mol/h / (1.6 s * 3600 s/h) = 5.2083 ft³.

To calculate the space-time, we divide the volume by the feed rate: Space-time = 5.2083 ft³ / 75 lb mol/h = 0.0694 ft³/lb mol/h.

Therefore, the volume of the reactor is 5.2083 ft³ and the space-time is 0.0694 ft³/lb mol/h.

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if these were to react to form nh3 molecules, what is the maximum number of nh3 molecules that could form?

Answers

To determine the maximum number of NH3 molecules that could form, we need to know the quantities of N2 and H2 available and identify the limiting reactant using the balanced chemical equation.

To determine the maximum number of NH3 molecules that could form, we need to consider the balanced chemical equation for the reaction. Without specific reactants mentioned in the question, I will assume we are referring to the synthesis of ammonia (NH3) from its elements.

The balanced chemical equation for the reaction is:

N2 + 3H2 → 2NH3

From this equation, we can see that 1 molecule of nitrogen gas (N2) reacts with 3 molecules of hydrogen gas (H2) to form 2 molecules of ammonia (NH3). Therefore, the stoichiometry of the reaction indicates that the ratio of N2 to NH3 is 1:2.

Given that we want to find the maximum number of NH3 molecules that can form, we need to determine the limiting reactant. The limiting reactant is the reactant that is completely consumed first, thus limiting the amount of product formed.

To do this, we need to know the quantities of N2 and H2 available. Without this information, we cannot provide a specific numerical answer. However, it is important to note that the maximum number of NH3 molecules that could form will be determined by the quantity of the limiting reactant.

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Assuming the volume of the stomach to be 1. 0 L, what will be the pH change of the stomach acid resulting from the ingestion of one Tums ultra 1000 tablet that contains 1000 mg of cal- cium carbonate

Answers

The ingestion of one Tums Ultra 1000 tablet, containing 1000 mg of calcium carbonate, can cause a pH change in the stomach acid due to the antacid properties of calcium carbonate.

Calcium carbonate is a common ingredient in antacid tablets like Tums Ultra 1000. It works by neutralizing excess stomach acid, raising the pH level and reducing the acidity. The pH scale measures the acidity or alkalinity of a solution, with lower pH values indicating higher acidity.

The exact pH change resulting from the ingestion of one Tums Ultra 1000 tablet depends on several factors such as the concentration of the stomach acid and the buffering capacity of the tablet. However, in general, calcium carbonate reacts with stomach acid (hydrochloric acid) to form water, carbon dioxide, and calcium chloride. This reaction reduces the concentration of hydrochloric acid, thereby increasing the pH of the stomach acid.

The specific calculation of the pH change requires more information, such as the initial pH of the stomach acid and the exact concentration of the tablet's active ingredient. Nevertheless, the antacid properties of calcium carbonate in Tums Ultra 1000 can effectively raise the pH of the stomach acid and provide relief from symptoms of acidity.

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which explains how the nervous system is typically involved in keeping the body in Homeostasis?​

which explains how the nervous system is typically involved in keeping the body in Homeostasis?

Answers

its c because of the thing on the....

Answer:

c because this is the one hundred all the time

Explanation:

which explains how the nervous system is typically involved in keeping the body in Homeostasis?

The ratio of boys to girls at a school
dance is shown in the graph.
0
1
2
3
4
5
6
7
8
9
123456789
Number of Girls
Number of Boys
x
y
Which equation has a greater rate
of change than the rate shown in
the graph?
a. y 5 __
1
5 x
b. y 5 __
1
7 x
c. y 5 __
2
9 x
d. y 5 __
2
3 x

Answers

Answer:

Si tú puedes 1-2-3-4-5-6-7-8-9-10 eso debes de ser más bien dicho sacaran Club Ojalá que te ayude Chau

Explanation:

de Ojalá que te ayude No te olvides de sacar todas las preguntas esas lo que tú dijiste y si tú promoción 123 saquen globo que quieras tú

give the iupac name for (ch3)2c=chch2ch2oh. spell out the full name of the compound.

Answers

The IUPAC name for the given compound \((CH_3)_2C=CHCH_2CH_2OH\) is 3-hydroxy-2-methylbut-2-ene.

First, we identify the longest continuous carbon chain, which consists of five carbon atoms. This forms the parent chain, which is a butene.

Next, we locate the double bond, which is between the second and third carbon atoms. Since the double bond starts at the second carbon atom, we indicate it as "but-2-ene."

Moving on, we need to indicate the presence of substituents. In this case, we have a methyl group attached to the second carbon atom. Therefore, we include the prefix "2-methylbut-2-ene."

Lastly, there is a hydroxyl group (-OH) attached to the fourth carbon atom. We denote this as "hydroxy" and specify the position of the hydroxyl group, resulting in the full name "3-hydroxy-2-methylbut-2-ene."

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Which of the following explains why 4-aminophenol is acetylated at the amine group rather than the phenol group

Answers

The reason why 4-aminophenol is acetylated at the amine group rather than the phenol group is due to the difference in reactivity and nucleophilicity between the amine and phenol functional groups.

The amine group (–NH2) is more reactive and nucleophilic compared to the phenol group (–OH). This is because the lone pair of electrons on the nitrogen atom in the amine group is more available for nucleophilic attack.

When an acetylating agent, such as acetic anhydride (CH3CO)2O or acetyl chloride (CH3COCl), is used to acetylate 4-aminophenol, the amine group acts as a stronger nucleophile and readily reacts with the electrophilic acetylating agent. This results in the substitution of the hydrogen atom on the amine group with an acetyl group (–COCH3), leading to the formation of N-acetyl-4-aminophenol.

On the other hand, the phenol group in 4-aminophenol is less reactive and nucleophilic. The lone pair of electrons on the oxygen atom in the phenol group is less available for nucleophilic attack. Therefore, under the same conditions, the amine group is more likely to undergo acetylation instead of the phenol group.

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Which of the following explains why 4-aminophenol is acetylated at the amine group rather than the phenol group? the nitrogen is less electronegative than the oxygen the nitrogen is more electronegative than the oxygen the nitrogen is less sterically hindered than the oxygen the nitrogen is smaller than the oxygen Question 2 1 pts Starting with 3.00 g of 4-aminophenol (109.13 g/mol) and excess acetic anhydride (102.09 g/mol), what is the theoretical yield (in g) of acetaminophen ( 151.16 g/mol)?

What is the equation for density?
m
O DE
V
O D= V
m
m
O D =
DE
= 1 mu
D =

Answers

mass divided by volume

Answer: This may not work for you

Explanation: Density, mass of a unit volume of a material substance. The formula for density is d = M/V, where d is density, M is mass, and V is volume. Density is commonly expressed in units of grams per cubic centimetre.

. a perchloric acid solution has a ph of 3.158. what is the concentration of perchlorate ion in this solution?

Answers

The concentration of perchlorate ion in a perchloric acid solution with a pH of 3.158 can be calculated using the Henderson-Hasselbalch equation.Therefore, the concentration of perchlorate ion in the solution is 4.7 x 10^{-4} M.

Perchloric acid (HClO4) is a strong acid. A strong acid is a substance that almost entirely dissociates into ions when it dissolves in water. As a result, perchloric acid can be thought of as a source of hydrogen ions (H+) in solution.The concentration of hydrogen ions in solution can be determined using the pH of the solution. pH is the negative logarithm of the hydrogen ion concentration in moles per liter (mol/L) of solution.A pH of 3.158 corresponds to a hydrogen ion concentration of:10^{-3.158} = 6.59 x 10^{-4}  mol/LIn a perchloric acid solution, the perchlorate ion (ClO4) is the conjugate base of the acid. It can be concluded that the concentration of perchlorate ions (ClO4-) is equal to the concentration of hydrogen ions (H+) in the solution because the acid completely dissociates. Therefore, the concentration of perchlorate ions in a solution with a pH of 3.158 is 6.59 x 10^{-4} mol/L.Therefore, the answer is that the concentration of perchlorate ion in perchloric acid solution with a pH of 3.158 is 6.59 x 10^{-4 }mol/L.

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Jana is modeling mutations using the word "FRIEND."
Which version of the word "FRIEND' models a deletion mutation?
A FRIENDS
B. DRIEND
C. FIEND
D. DNEIRF

Answers

Answer:

It is c I am doing the test I hope this helps ; )

Explanation:

Answer:

c

Explanation:

lewis electron dot symbol of Ag⁴⁷

Answers

Answer:

Ag one dot

Explanation:

i hope it helps you

1. Which term identifies a factor that will shift a
chemical equilibrium?
A) atomic radius
B) catalyst
C) decay mode
D) temperature

Answers

Answer:

D) Temperature,

Explanation:

Why are there more sodium ions in the sulfide compound

Answers

Answer:

2 Na

Explanation:

2 Na atoms per 1 Sulfide atom

hope this helps

Since sodium sulfide is a neutral salt, each sulfide ion requires 2×Na+ ions

Sorry, I have another question! Please answer as soon as possible:)

Sorry, I have another question! Please answer as soon as possible:)

Answers

Answer:

I think its b

Explanation:

Sorry if wrong! Hope this helps tho! maybe mark me brainliest if I am?

SOMEONE, PLEASE ANSWER MY CHEMISTRY QUESTION ASAP WILL MARK BRAINLIST ASAP

Answers

Answer:

Whats the question? I can try and help you

Explanation:

PLEASEEEE HELPPPPP!!

PLEASEEEE HELPPPPP!!

Answers

Answer:

Its the first one

Explanation:

4 mol is the highest of the Bunch and 4.0L is the lowest making the first answer the correct one

you have 10 kg each of a radioactive sample a with a half-life of 100 years, and another sample b with a half-life of 1000 years. which sample has the higher activity?

Answers

If you have 10 kg each of a radioactive sample a with a half-life of 100 years, and another sample b with a half-life of 1000 years, sample A has a higher decay constant and higher activity.

The activity of a radioactive sample refers to the number of decays occurring per unit time. It is measured in units of becquerels (Bq) or curies (Ci). The activity of a sample is proportional to the number of radioactive nuclei present in the sample.

The decay rate of a radioactive sample is determined by its half-life. The shorter the half-life, the higher the decay rate and the higher the activity. Therefore, sample A with a half-life of 100 years will have a higher decay rate and higher activity than sample B with a half-life of 1000 years.

To calculate the activity of a sample, we use the following formula

Activity = λN

where λ is the decay constant, and N is the number of radioactive nuclei present in the sample.

Since the two samples have the same mass, the number of radioactive nuclei will be the same. Therefore, the sample with the higher decay constant (λ) will have the higher activity.

The decay constant is related to the half-life by the following formula:

λ = ln(2) / \(t^{\frac{1}{2} }\)

where ln(2) is the natural logarithm of 2, and \(t^{\frac{1}{2} }\) is the half-life.

Using this formula, we can calculate the decay constants for samples A and B

\(\lambda_{A}\)= ln(2) / 100 years = 0.00693 per year

\(\lambda_{B}\) = ln(2) / 1000 years = 0.000693 per year

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About which other carbon–carbon bonds may rotation occur on 2 methylhexane

Check all that apply.

C-1−C-2 bond
C-2−C-3 bond
C-4−C-5 bond
C-5−C-6 bond
C-2−C-7 bond

Answers

The carbon-carbon bonds where rotation can occur on 2-methylhexane are the C-1−C-2 bond, C-2−C-3 bond, and C-5−C-6 bond.

Rotation is possible around single bonds, and in 2-methylhexane, these bonds are all single bonds. The C-1−C-2 bond, C-2−C-3 bond, C-4−C-5 bond, and C-5−C-6 bond are all single bonds, allowing for free rotation. On the other hand, the C-2−C-7 bond is not present in 2-methylhexane and therefore rotation cannot occur on that specific bond.

In 2-methylhexane, rotation can occur around the following carbon-carbon bonds:

C-1−C-2 bond: Yes, rotation can occur around this bond.

C-2−C-3 bond: Yes, rotation can occur around this bond.

C-4−C-5 bond: No, rotation cannot occur around this bond because it involves the methyl group attached to the second carbon, which creates a hindered rotation.

C-5−C-6 bond: Yes, rotation can occur around this bond.

C-2−C-7 bond: No, rotation cannot occur around this bond because it involves the methyl group attached to the second carbon, which creates a hindered rotation.

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in a naturally occurring sample, 69.2 % of copper atoms have 34 neutrons and 30.8 % have 36 neutrons. what is the average mass of the atoms in your drawing? (copper-63 has a mass of 62.92960 amu , and copper-65 has a mass of 64.92779 amu .)

Answers

The average mass of the copper atoms in the sample is 63.4622232 amu.

The average mass of the copper atoms in the sample can be calculated by multiplying the mass of each isotope by its percentage abundance and summing the results.

Copper-63: 69.2% x 62.92960 amu = 43.480832 amu
Copper-65: 30.8% x 64.92779 amu = 19.9813912 amu

Adding these values together:

43.480832 amu + 19.9813912 amu = 63.4622232 amu

Therefore, the average mass of the copper atoms in the sample is 63.4622232 amu.

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A tortoise uses its eyes to see something moving nearby. The tortoise feels threatened by the movement. It pulls its head, legs, and tail into its shell. The tortoise's shell is hard and thick. This helps protect the turtle's soft body parts from any danger. Which of these describes a response of the tortoise to sensory information processed by its brain?

A. The tortoises shell is hard and thick.

B. The tortoise pulls its head, legs, and tail into its shell.

C. The tortoises soft body parts are protected from any danger.

D. The tortoise uses its eyes to see something moving nearby.​

Answers

The answer is b because the torise pulls it’s head and legs both

What is the name of the compound (NH4)2SO4

Answers

The answer is Ammonium sulfate

Which of the following are cations? Check all that apply.

a
barium
b
calcium
c
oxygen
d
chlorine
e
aluminum
f
magnesium
g
copper
h
bromine

Answers

Answer:

a

barium

b

calcium

e

aluminum

f

magnesium

g

copper

Forms cation

Explanation:

Suppose 0. 270g of barium acetate is dissolved in 50. ML of a 37. 0mM aqueous solution of sodium chromate.


Calculate the final molarity of acetate anion in the solution. You can assume the volume of the solution doesn't change when the barium acetate is dissolved in it.


Round your answer to 2 significant digits

Answers

The final molarity of the acetate anion in the solution is 0.04 mM.

To calculate the final molarity of acetate anion in the solution, we need to know the mass of barium acetate that was dissolved and the number of moles of acetate anion that it contains.

Barium acetate has the formula Ba(C2H3O2)2, which means that it contains 1 mole of Ba, 2 moles of C2H3O2, and a total of 3 moles of ions. Since we are interested in the molarity of acetate anion, we need to calculate the number of moles of C2H3O2 that are present in 0.270 g of barium acetate.

The molecular weight of barium acetate is 244.26 g/mol, which means that 0.270 g of barium acetate contains 0.270 g / 244.26 g/mol = 0.0011 moles of barium acetate. Since each mole of barium acetate contains 2 moles of C2H3O2, this means that 0.0011 moles of barium acetate contain 0.0011 moles × 2 moles/mole = 0.0022 moles of C2H3O2.

The initial molarity of the solution is 37.0 mM, which means that it contains 37.0 moles/L of sodium chromate. The volume of the solution is 50.0 mL, which means that it contains 50.0 mL × 37.0 moles/L = 1.85 moles of sodium chromate.

When 0.270 g of barium acetate is dissolved in the solution, the total number of moles of ions increases by 0.0022 moles. This means that the final molarity of the acetate anion in the solution is:

Molarity = (total number of moles of ions) / (volume of solution)

= (1.85 moles + 0.0022 moles) / (50.0 mL)

= 0.037 mM

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Balance these equations : ) ……H 2 + …..O 2 —> …. H 2 O…..FeCl 2(s) + ….. H 2 O (1)….> ….FeO (s) + …. HCl(aq)…..C 4 H 8(g) + …..O2(g)……> ….CO 2(g) + ….H 2 O (l)…..NaHCO 3(s) ….> ……Na 2 CO 3 + ….. CO 2(g) +…..H 2 O (g)…..NaOH (aq) + …….NgCl (aq) ….> …..NaCl (aq) + ….Mg(OH) 2(s)

Answers

In order to properly balance an equation, we need to make sure that the same amount of elements on the reactants side matches the number of elements on the products side, we can do that by increasing the number in front of each molecule, the so called stoichiometric coefficient. In the reaction from the question we can properly balance by adding the following stoichiometric coefficients

1. 2 H2 + O2 -> 2 HO2

2. FeCl2 + H2O -> FeO + 2 HCl

3. C4H8 + 6 O2 -> 4 CO2 + 4 H2O

4. ?

5. 2 NaOH + MgCl2 -> 2 NaCl + Mg(OH)2

give the orbital configuration of the following elements using the s, p, d, f type representation. (answer format is: 1se2 = 1s 2 ) helium, nitrogen, silicon helium nitrogen silicon

Answers

These orbital configurations represent the arrangement of electrons within the different energy levels and subshells of the respective elements.

The orbital configurations of the given elements are as follows:

Helium: 1s² - Helium has two electrons that occupy the 1s orbital.

Nitrogen: 1s² 2s² 2p³ - Nitrogen has two electrons in the 1s orbital, two electrons in the 2s orbital, and three electrons in the 2p orbital (specifically, 2p³ indicates three electrons in the 2p subshell).

Silicon: 1s² 2s² 2p⁶ 3s² 3p² - Silicon has two electrons in the 1s orbital, two electrons in the 2s orbital, six electrons in the 2p orbital, two electrons in the 3s orbital, and two electrons in the 3p orbital (specifically, 3p² indicates two electrons in the 3p subshell).

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Please help, I will give you brainliest which amounts of money can be formed using just two- dollar bills and five-dollar bills? prove your answer using strong induction. A bullet with mass 5.07 g is fired horizontally into a 2.070kg block attached to a horizontal spring. The spring has a constant 5.5410 2N/m and reaches a maximum compression of 5.88 cm. (a) Find the initial speed of the bullet-block system. Use energy conservation to relate the initial energy of the spring-bullet-block system to its final energy. m/s (b) Find the speed of the bullet. Once you know the initial speed of the bullet-block system, use momentum conservation to relate the speed of the bullet before the collision to the speed of the system afterward. m/s although he often worked for catholic patrons, lucas cranach the elder was a champion of what religion? multiple choice question. puritanism protestantism islam anglicanism Five explorers plan to share them equally. How many jewels does each get. There are various methods of restructuring that firmscan follow in the process of turning around a venture in financialdistress. Which do you think are most effective? Why? Astronomers find stars that are 10 kpc from the center of the Milky Way and measure that the stars are orbiting around the Galaxy with a velocity of 200 km/s. What is the mass of the Milky Way within a radius of 10 kpc? Read this sentence:Other people found clowns frightening, but Sonia couldn'tunderstand why.What word should you change in the sentence to switch its point of view from thirdperson to first person?A. Change "Sonia" to "she."B. Change "other people" to "you."C. Change "other people" to "they."OD. Change "Sonia" to "I." What is a problem with the educational system in Paraguay?lack of attendancelack of studentslack of teacherslack of schools Dwayne is an anthropologist examining the skeleton of a young man and covered at a dig. He closely look at the man's teeth and bone structure eventually making a determination that this must be a peasant farmers how does Duane notice using the example explain how a person's economic situation can I have an impact on their health. ASAP what causes the earth to orbit just like Mars HELP PLEASE GIVING 30 POINTS AND BRAINLIEST DUE VERY SOON!! which short-term goal would a nurse develop when planning care for a client 1 week after the client experienced a spinal cord injury at the t 3 level? A rectangular rug is 12.5 feet long and 10 feet wide. The rug needs to be reduced by a factor of One-fifth. What is the area of the reduced rug? enterprise systems require data transfersoften to mainframes.;t/f What sensation does Farquhar experience with terrible suddenness which details suggest that Farquhar's escape occurs in his mind? which point lies on the graph of y = -|x| -5? A tank has two rooms separated by a membrane Room A has 1 kg of air and a volume of 0.6mroom B has 0.8 m 'of air with density 0.9 kg /m The membrane is brokenand the air comes to a uniform state Find the final density of the air? if f(x)=0 what is x What are the 5 basic freedoms of the First Amendment?